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Clinical Evidence

Photobiomodulation as a treatment for neurodegenerative conditions is an active and growing area of research, with numerous completed studies and ongoing clinical trials. Below is a summary highlighting the research supporting PBM's efficacy as a treatment option for Alzheimer's Disease.

Saltmarche et al., “Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report,” Photomedicine and Laser Surgery, vol. 35, no. 8, pp. 432-441, 2017.

Blanco et al., “Transcranial infrared laser stimulation improves rule-based, but not information-integration, category learning in humans,” Neurobiology of Learning and Memory, vol. 139, pp. 69-75, 2017.

L. L. Chao, “Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial,” Photomodulation, Photomedicine and Laser Surgery, vol. 37, no. 3, pp. 133-141, 2019.

Berman et al., “Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition,” Neurol Neurosci., vol. 8, no. 1, p. 176, 2017.

Salehpour et al., “Rapid Reversal of Cognitive Decline, Olfactory Dysfunction, and Quality of Life Using Multi-Modality Photobiomodulation Therapy: Case Report,” Photobiomodul Photomed Laser Surg., vol. 37, no. 3, pp. 159-167, 2019.

Zomorrodi et al., “Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study,” Scientific Reports, vol. 9, no. 1, pp. -, 2019.

Nizamutdinov et al., “Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia,” Aging and Disease, vol. 12, no. 4, pp. 954-963, 2021.

Lee et al., “Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies,” Ageing Research Reviews, vol. 83, p. e101786, 2023.

Liu et al., “Transcranial photobiomodulation with near-infrared light: a promising therapeutic modality for Alzheimer's disease,” Neural Regeneration Research, vol. 18, no. 9, pp. 1944-1945, 2023.

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